Intra-articular aprotinin versus steroids in osteoarthritis of the knee

ABSTRACT

The results of intra-articular Injection of aprotinin and corticosteroids have been assessed by a double-blind trial design in 32 symptomatic osteoarthritic knees. Aprotinin produced a better and longer-lasting symptomatic relief than steroids. Whereas steroids are used only for symptomatic relief in osteoarthritis, aprotinin may in addition effect a genuine cure of the diseased joint through inhibition of the proteolytic enzymes responsible for carticlage breakdown