Pervention of surgically induced peritoneal adhesions in rabbits by solcoseryl

ABSTRACT

Thirty one pregnant female rabbits were used in the present study. For induction of adhesions, all animals received a standardized injury to their uterine horns a preximal part of fallopian tubes. The animals were then divided into five equal groups; the 1st group was kept as a control group; animals in the 2nd group were treated by I.M. hydrocortisone; animals in the third group were treated with I.M. solcoseryl; animals in the forth group were treated locally by solcoseryl jelly which was introduced intraperitoneally to cover all areas of injury prior to abdominal closure; animals in the last group were treated with solcoseryl locally together with I.M. injection. Two weeks later, laporatomy was done to each animal and adhesions were scored. It was found that both hydrocortisone and solcoseryle significantly reduced the adhesion formation as compared with the control group. The inhibitory action of hydrocortisone did not differ significantally from the results obtained by solcoseryl when used either locally or by I.M. injection. However, the difference was significant when solcoseryly was given I.M. concomitantly with local application