[Effects of vitamin E supplementation on activity of serum paraoxonase, SOD, GPX enzymes and lipid profiles in beta major thalassemia patients]
Journal of Gorgan University of Medical Sciences. 2012; 13 (4): 35-43
in Persian
| IMEMR
| ID: emr-124469
ABSTRACT
In pathogenesis of beta major thalassemia, tissue damage is occurring due to oxidative stress. The present study was designed to evaluate the effects of vitamin E supplementation on serum Paraoxonase, SOD, GPX enzyme activity and lipid profiles in beta major thalassemia patients. In this clinical tiral study, Sixty [25 males, 35 females] beta major thalassemia patients with age >/= 18 years who had criterias to enter the study, were selected randomely in two groups. The patients in interventional group, vitamin E at a dose of 400 mg/day were given for three months, with no supplementations in control group. The enzyme activities of paraoxonase, SOD, GPX and lipid profiles [LDL-c, HDL-c, triglyceride, total Antixidant Capacity] were measured prior and after 3 months in both case and control groups. Data analyzed by using paired t-test. Significant increases in serum levels of vitamin E, Paraoxonase activity, HDL cholesterol [P<0.001], BMI [P = 0.001] and a significant reduction in GPX activity [P<0.05] were observed in cases compared to controls. The vitamin E supplementation may be useful in reducing oxidative stress and lipid profiles in beta major thalassemic patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Superoxide Dismutase
/
Triglycerides
/
Beta-Thalassemia
/
Oxidative Stress
/
Aryldialkylphosphatase
/
Glutathione Peroxidase
/
Lipids
/
Cholesterol, HDL
/
Cholesterol, LDL
/
Antioxidants
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
Persian
Journal:
J. Gorgan Univ. Med. Sci.
Year:
2012
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