Acid-base status and electrolyte shifts during transuretheral resection of the prostate

ABSTRACT

Metabolic changes underlying TURP have not yet been fully investigated. This attracted attention to investigate both the electrolyte and acid-base shifts after TURP in 39 patients. They were divided into two groups according to the use of either distilled water or glycine 1.5% for irrigation during the procedure. Nalbuphine was given for premedication and carbocaine 4% for spinal analgesia. During surgery, ECG, HR and BP were monitored; while serum electrolytes and acid-base data were determined pre- and postoperatively. Significant degrees of hyponatremia have characterized the use of either irrigating solution. Nonsignificant rise of serum potassium followed distilled water irrigation. More metabolic acidosis took place with glycine irrigation. TUR syndrome was diagnosed in one patient with glycine irrigation and was properly treated. It was concluded that the search for an irrigation solution with closer properties to ideality is m and atory. Important practical points for anaesthesia and surgery during TURP were recommended for consideration