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Cetirizine and loratadine - comparing their antagonist effects on isolated trachea of rabbit
Medical Forum Monthly. 2011; 22 (7): 23-27
in English | IMEMR | ID: emr-124620
ABSTRACT
To study and compare the antagonist effects of Cetirizine and Loratadine on histamine induced contractions of isolated trachea of rabbit. Comparative controlled invitro experimental study. This study was conducted at The Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute [BMSI] Jinnah Postgraduate Medical Center [JPMC] Karachi, for the period of six months. Isolated tracheal smooth muscles of twenty four rabbits were used. Fresh Kreb's nutritional solution was prepared for each subject. Tracheal smooth muscles were exposed to standard dilution of Histamine, and then they were challenged with serial dilutions [10 [-18]to 10 [-3]gm. /ml] of Cetirizine and Loratadine separately. Responses as rate and amplitudes of contractions were recorded by 7B Grass Polygraph machine. Cetirizine inhibit the rate of histamine induced contractions of tracheal muscles from 0.85 to 12.33% and amplitude from 0.0 to 82.69%, as concentration of drugs increased. While Loratadine inhibit the rate of histamine induced tracheal contractions from 0.85 to 10.59% and amplitude from 6.5 to 76.82% as concentration of drugs increased. Cetirizine found more potent than Loratadine as inhibitor of histamine induced contraction in isolated tracheal smooth muscles of rabbit. Basic Sciences
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Index: IMEMR (Eastern Mediterranean) Main subject: Rabbits / Trachea / Histamine / Loratadine Limits: Animals Language: English Journal: Med. Forum Mon. Year: 2011

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Index: IMEMR (Eastern Mediterranean) Main subject: Rabbits / Trachea / Histamine / Loratadine Limits: Animals Language: English Journal: Med. Forum Mon. Year: 2011