Role of stem cell and new regenerative therapies in endodontics

ABSTRACT

Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many condition, an ideal form of therapy might consist of regenerative approach in which a biologically based procedures designed to replace damaged structures, including dentin, root structure and pulp-dentin complex. The aim of this study was to collect information about the stem cell and their role in new regeneration therapies in endodontics. Data was collected by searching Pubmed and Cochrane data bases using key words such as stem cell, regenerative endodontics, pulp revascularization and tissue engineering. Selected reference text books were searched using the same search strategy. The search results were categorized according to methodological strength; they also selected only if qualified for our inclusion criteria. Although regenerative endodontic procedures are much more effective in regeneration of pulp-like tissues, [pulp-dentin complex], and despite these applications and considerable evolution of certain medical procedures of tissue regeneration, there has not been significant translation of these therapies into clinical endodontic practice. More studies are required to overcome technical and clinical limitations of pulp and dentin tissue regeneration both to result in pulp-dentin tissue regeneration, and to form the functional structure of the tooth from stem cells