Schistosoma mansoni ova output and some immunogenic parameters in hepatic schistosomiasis: a possible relation

ABSTRACT

The present work was designed to study the relations between S. mansoni ova output the HLA system and the immune responsiveness in patent patients with hepatic schistosomiasis. The work included 20 unrelated male patients with active intestinal schistosomiasis and in a state of early schistosomal hepatic affection, as well as 20 normal controls. The incidence of HLA-A28 and HLA-B5 was found to be significantly higher in the patients than in controls. No relation could be detected between S. mansoni egg excretion and the HLA system, the humoral or the cellular immune parameters in the studied patients. The present work suggested that though the major histocompatibility complex may not influence the susceptibility to S. mansoni infection, it has an effect on the outcome of this infection