Serum sialic acid and its lipid and protein bounds as possible biomarkers of acute myocardial infarction in Erbil city

ABSTRACT

Myocardial infarction [MI] usually occurs when coronary blood flow decreases abruptly after a thrombotic occlusion of a coronary artery previously affected by atherosclerosis. Sialic acid [SA] is attached to non reducing residues of the carbohydrate chains of glycoproteins and glycolipids. An elevation in serum TSA, LBSA and PBSA concentrations has been observed in a number of pathological conditions .The aim of the study was to determine the serum TSA and its LBSA and PBSA in patients with acute myocardial infarction [AMI]. Serum TSA, LBSA and PBSA concentrations were evaluated by UV/VIS spectrophotometry in [100] apparently healthy individuals and [100] newly diagnosed AMI patients. The mean levels of serum TSA, LBSA and PBSA in AMI patients were significantly higher [P<0.05] than those of apparently healthy individuals. The results indicate that the serum values of TSA, LBSA and PBSA appeared to be of a value in diagnosis of AMI