[Changes of serum biochemistry in short term toxicity with lindane pesticide in broiler chickens]

ABSTRACT

Lindane is highly lipid soluble toxin and persist in the environment, Its bioaccumulation occurs in the food chain from the environment to animals and humans. In order to evaluate the effects of high doses of lindane on the weight and serum biochemical parameters, twenty five old Ross broiler chicks [30day] were divided into control and 4 treatment groups of 5 chickens each. The chickens of control group didn't receive any toxin but the other groups received diets containing 150, 300, 600 and 900 ppm, lindane respectively. At the end of seventh day, animals were weighed and exsanguinated. Liver and blood samples were collected. The chicken weight decreased significantly in response to 600 and 900 ppm lindane compared to control, 150 and 300 ppm groups. The kidneys were affected in all groups compared to the control. Serum uric acid increased significantly. Although malfunction of kidneys were more severe in 900ppm titan the other groups. In 900 ppm group increased activity of AST were significant comparing to control and another groups [p<0.05]. Comparing to control and all groups the activity of CPK in the 900ppm increased significantly [p<0.05]. The other parameters in seum such as total protein, albumin and globulin, triglyceride cholesterol, LDL-cholesterol, HDL-cholesterol and VLDL Index of lipid peroxidation byTBARs method and also beta carotene and vitamine A in serum and liver were not significant. So for evaluating of toxic effects of short term lindane administration, initially suggest that measure kidneys test [specially uric acid] and muscle test [specially AST and CPK] and should be not that the weight measuring is very important