Vitamin B12 for the treatment of recurrent aphthous stomatitis

ABSTRACT

The purpose of this study was to confirm the beneficial effects of Vitamin 12 in the treatment of Recurrent Aphthous Stomatitis. This study was conducted at the Department of Oral Medicine of Khyber College of Dentistry, Peshawar on 65 patients suffering from Recurrent Aphthous stomatitis. The patients were randomly divided in to two groups A sublingual dose of Vitamin B12 500 mcg and 1000 mcg was administered to the two groups for 6 months. There were 35 patients in Group-I who were given l000mcg Vitamin B 12 sublingually while in Group-II, 30 patients were given 500 mcg Vitamin B 12 sublingually for 6 months at bed time. The parameter has been recorded in each group on monthly basis for 6 months. The level, duration of pain, the number of outbreak and the size of ulcer was considerably reduced in patients who were treated with Vitamin B 12 l000mcg irrespective of blood Vitamin 12 level as compared to patients taking 500 mcg Vitamin B 12. There was no Recurrent Aphthous stomatitis in Group-I at the end of 6 months while in Group-II there was 30% relief. Thus Vitamin B 12 1 000 mcg sublingually in the treatment of Recurrent Aphthous ulceration is a safe, effective, inexpensive and low risk treatment regardless of serum Vitamin B 12 level in the blood