effect of hydration and epidural analgesia on the P-50 in pre-eclamptic patients

ABSTRACT

Twenty subjects suffering from preeclampsia were included in this study and divided into two groups 11 cases in GI [mild] and 9 cases in GII [severe] PET. P-50 in both groups was shifted to the left. After hydration only, insignificant changes in P-50 were observed; but after epidural analgesia, a significant shift to the right was observed, this may be attributed to the significant improvement of pH. Significant increase in venous oxygen tension and venous oxygen saturation in both groups which may result from decreased oxygen needs to the paralyzed part and vasodilatation with increase blood flow to affected organs. An elevation in PH enhanced 2,3 PDG phosphatase. This led to an increased synthesis of 2,3-DPG and increased level of 2,3- DPG which might be the cause of increased P-50 after epidural analgesia