Effect of sodium valproate on bone profile in children in Al Jahra area [Kuwait]

ABSTRACT

Many studies observed the significant effect antiepileptic medication on the bone profiles in epileptic patient. As well as many other known side effects [1]. Is to assess the laboratory effect of prolonged use of sodium valproate on bone profiles. This study was carried out in Al-Jahra hospital, Kuwait. Which is a general governmental hospital, serving more than 350000 population One hundred patients were included in this study [62 males and 38 females] with age ranging from 3-9 years with mean age 5.5 years. They were divided into 2 groups-Group I [patients group] Fifty children [34 males and 16 females] with age ranging between 3-9 years, who are known to have epilepsy, were diagnosed based on clinical and EEG finding and started on sodium valproate. All patients who are bed ridden or have global developmental delays were excluded from the study. Also patient who are falling to thrive were excluded. Group 2 [control group] Fifty healthy children [28 female and 32 male] with age ranging between 2-6 years. With no risk factor of epilepsy. Any child had any seizure disorder was excluded from the study Each group of the studied children was subjected to thorough clinical history taking as well as detailed clinical examination [general and neurrological examination] any patient have neurological deficit were excluded from the study. Both groups were subjected to the following laboratory tests to determine the effect of sodium valoprate on bone profile [Serum Calicum, phosphorus, alkaline phosphate] as well as vitamin D metabolite