Clinico-pathological analysis of hysterectomies in various age groups at Hyderabad, Pakistan

ABSTRACT

To study the frequency and pattern of benign, premalignant, and malignant lesion in hystrectomized uteri and perform clinic-pathological analysis. All hysterectomy specimens received in the histopathology departments of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Hyderabad during the period of January 2005 to December 2006 were studied. A randomized study of 100 cases undergoing hysterectomy was carried out and clinicopathological analysis was done. Most women who underwent hysterectomy were in the age group of 25-75 years. Two proformas were designed to record the clinical information and gross and histopathological findings. Specimens were preserved in 10% formalin and thorough gross examination was done. Representative blocks were processed for paraffin embedding. Abnormal menstrual flow was the most common complaint. Mean age of the patient was 43.06 +/- 7.34 years. Out of 100 cases, endometrial diseases were the most common finding [in67% of the cases] followed by adenomyosis [47%], leiomyoma [32%], cervical intraepithelial neoplastic changes [04%], and invasive cervical carcinoma [03%]. This study concludes that benign uterine lesions are common, consisting mostly of endometrial hyperplasia, leiomyoma, and adenomyosis, and are almost equally present in women above and below the age of 40 years in Hyderabad with the exception of endometrial carcinoma and invasive cervical carcinoma which were commonly found above 40 years of age