[Comparison of effectiveness of extra-amniotic PGE[2] and high-dose oxytocin in induction of abortion]

ABSTRACT

Medical and surgical methods are used for induction of abortion. Prostaglandins are used in various forms such as vaginal tabs, gels, intra-amniotic and extra-amniotic injections. The object of this study was to compare the effectiveness of extra-amniotic PGE[2] and high-dose oxytocin in induction of abortion. The study included 60 women admitted for induction of abortion in Shahid Sadoughi hospital of Yazd from 2007 till 2009. They were randomly allocated in two groups. Data was collected by a questionnaire and statistical tests such as Fisher's exact and chi square were used for analysis of data. The success rate of PGE[2] group [P=0.014] was higher than oxytocin group. The mean time of induction of abortion in PGE[2] method was shorter than oxytocin method [p=0.0001]. In both the two groups, the mean time of induction of abortion in dead fetuses was shorter than that in live fetuses [p=0.0001 for PGE[2] group and =0.011 for oxytocin group]. There was no significant difference in the rate of complications of treatment in the two groups. In both the two groups, the mean time of induction of abortion in the 12-14 weeks period was longer than 8-11 and 15-19 weeks, which was significant in the PGE[2] group [p=0.001]. The use of extra-amniotic PGE[2] method in induction of abortion is more effective than high-dose oxytocin and by decreasing the induction period and need for curettage, hospitalization period and expenditure ca be decreased leading to increased satisfaction of patients