Immunohistochemical localization of keratin in 100 cases of squamous cell carcinoma
Pakistan Journal of Pathology. 2009; 20 (3): 81-84
in English
| IMEMR
| ID: emr-125570
ABSTRACT
The keratinizing tumors are less radiosensitive and non-keratinizing are more radio responsive. This study was carried out to detect the presence of keratin in apparently non- keratinizing poorly differentiated squamous cell carcinomas by immunoperoxidase staining. It is a cross sectional and descriptive study conducted at King Edward Medical College, Post Graduate Medical Institute, Lahore. A total of 100 patients suffering from squamous cell carcinomas were included in the study. Both H and E and immunoperoxidase staining were performed. The results of both types of staining were compared for each case. Four groups were identified. Forty nine cases showed obvious keratinization on both H and E and immunoperoxidase staining. Twenty cases had doubtful keratinization on H and E but showed more obvious keratinizaton on immunoperoxidase staining. Ten cases were non-keratinizing on H and E as well as on immunoperoxidase analysis. Cytokeratin can be used as a tumour marker for squamous cell carcinoma. The immunohistochemical technique can help us in revising and modifying our H and E impression of a squamous cell carcinoma
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunohistochemistry
/
Biomarkers, Tumor
/
Cross-Sectional Studies
/
Immunoenzyme Techniques
/
Keratins
Type of study:
Prevalence study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Pak. J. Pathol.
Year:
2009
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