[Studying the relationship between dissolution and absorption of the oral dosage forms locally manufactured containing macrolides and beta-lactam groups using Schulman cell]

The aim of the present study was to develop a model that can predict gastrointestinal absorption for a diverse range of drugs using the immobilized artificial membrane retention properties and the selected diffusion cell [schulman type]; the proposed method was employed to evaluate the apparent permeability of a set of 12 structurally diverse drugs having different solubility and permeability properties. An excellent linear correlation [R[2]=0.92] was obtained between the developed cell apparent permeability and human absorption data. A comparison of permeation data of some drugs obtained using retention properties of the immobilized artificial membrane [LAM] and the corresponding HIV values in humans further confirmed the proposed permeation method as predictor of the oral absorption of passively absorbed drugs. A comparative study between the permeability data for some solid dosage forms which belong to class III and class IV, and dissolution profile data can explain the effect of the permeability enhancers and formulation on the mechanism of drug absorption