IJPM-International Journal of Preventive Medicine. 2013; 4 (2): 158-164
in English
| IMEMR
| ID: emr-126173
ABSTRACT
There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. This study was performed in four groups of rats [1] Saline group, which received saline in the self-administration session. [2] Morphine group, which received morphine in saline solution in the self-administration session. [3] Baclofen + Morphine group, which received both baclofen 20 min before self- administration test and morphine in the self-administration session. [4] Phaclofen + Morphine group, which received both phaclofen 20 min before self- administration test and morphine in the self-administration session. The number of lever pressing and self-infusion were recorded. Morphine significantly increased the number of active lever pressing dose dependently in self-administration session in comparative with saline group. Administration of baclofen, 20 min before morphine self-administration produced significant decrease in the initiation of morphine self-administration during all session. Conversely, pre-treatment of phaclofen increased the number of active lever pressing and self-infusion in this test. Our results indicated a short-term treatment by baclofen, reduced morphine-maintenance response in a dose-dependent manner, suggesting that GABAB receptor agonists could be useful for reversing the neuroadaptations related to opiates
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Baclofen
/
Self Administration
/
Rats, Wistar
/
Receptors, GABA-B
/
Morphine Dependence
Limits:
Animals
Language:
English
Journal:
Int. J. Prev. Med.
Year:
2013
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