Adverse effects of marbofloxacin in male rats

ABSTRACT

The present work was a trial to study the effect of marbofloxacin on the reproductive system in male Albino rats. Moreover, some biochemical parameters were also examined. Fourty five mature male Albino rats weighing from 140- 180 gm each of 4-5 month old were used in this study. The animals were divided into 3 equal groups each of 15 rats. The first and second groups were injected I/M for 5 consecutive days with marbofloxacin at the dose level of 7.2 mg/ Kg B.Wt and 14.4 mg/ Kg B.Wt. respectively. The third group was kept as control and injected I/M with 0.3 mL saline /rat for 5 consecutive days. The obtained results showed that administration of marbofloxacin induced a variety of adverse effects. These are represented by certain fertility troubles as reduction of testes, epididymis and accessory sex organs weights, changes in sperm characters [decrease of sperm count and motility] and decrease of serum testosterone level. Moreover, the liver and kidney functions were significantly affected. Therefore, caution is required when using large doses of the drug of marbofloxacin due to its adverse effect on the sperm characters, liver and kidneys