Amino acid and peptide derivatives as anti-allergic and anti-inflammatory agents
Egyptian Journal of Chemistry. 2008; 51 (6): 807-821
in English
| IMEMR
| ID: emr-126450
ABSTRACT
It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. These compounds were structurally designed as 5-lipoxygenase inhibitors depending on two action mechanisms of the ready drugs used to treat allergy e.g.[Oxatomide], which contains piperzine moiety, its anti-allergic effects possess antagonist activities against chemical mediators such as histamine, serotonine and leukotrienes [which cause allergy]. Also, [Tranilast], which contains acrylic acid segment; its activity depends on inhibition of mediator release. In harmony with these findings new structures having anti-allergic properties are proposed in this manuscript. New products, [5a-u] with expected better biological activities and decreased side effects were synthesized by the addition of an amino acid conjugate of cinnamic acid to a piperazine segment. Their anti-allergic and anti-inflammatory activities were evaluated. Most of them show promising activities
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Peptides
/
Cinnamates
/
Anti-Allergic Agents
/
Anti-Inflammatory Agents
Language:
English
Journal:
Egypt. J. Chem.
Year:
2008
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