Role of soluble P-selectin among type 2 diabetic patients with and without coronary heart disease

ABSTRACT

Type 2 diabetes mellitus [T2DM] is associated with a marked increase in the risk of coronary heart disease. Platelets play a significant role in coronary artery disease [CAD]. P-selectin is a component of the platelet granule membrane that is expressed on the platelet surface membrane and shed into the plasma as sP-selection on platelet activation. The current study was performed to investigate the association of soluble P-selection with inflammatory marker high sensitivity C-reactive protein [hsCRP], lipid profile and glycemic control among type 2 diabetic patients with and without coronary heart disease. This study included 31 diabetic patients with coronary artery disease [group I], 29 healthy subjects as control group [group II], and 28 diabetic patients without coronary artery disease [group III]. The age and sex of diabetic groups were matched with normal control group. Glucose, HbAlc, lipid profile, hsCRP and sP-selectin were measured. The levels of glucose, HbAlc, total cholesterol, triacylglycerol. LDL-c, hsCRP and sP-selectin level were significantly higher in the diabetic group with coronary artery disease than in the control group and the diabetic group without coronary artery disease. The level of HDL-c was significantly lower in the diabetic group with coronary artery disease than in the control group and the diabetic group without coronary artery disease. There was a significant positive correlation between level of sP-selectin and duration of CAD diabetic patients with coronary artery disease. Also there was a significant positive correlation between sP-selectin and duration of diabetes mellitus in both diabetic groups with and without coronary artery disease. ROC curve analysis for hsCRP and sP-selectin indicated that, sP-selectin had higher sensitivity and specificity than hsCRP in diabetic patient with coronary artery disease. In conclusion, measurement of soluble P-selectin seems more helpful marker of impending coronary artery insult in diabetic patients and had higher diagnostic value than hsCRP in diabetic patient with coronary artery disease