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Serum interferon-alpha level in first degree relatives of systemic lupus erythematosus patients: correlation with autoantibodies titers
Egyptian Journal of Medical Human Genetics [The]. 2011; 12 (2): 139-146
in English | IMEMR | ID: emr-126708
ABSTRACT
Interferon-alpha [IFN-alpha], a cytokine with both antiviral and immune-regulatory functions, was suggested as a useful tool which can evaluate current systemic lupus erythematosus [SLE] disease activity and identify patients who are at risk of future disease flares. In the current study, serum IFN-alpha levels and associated demographic, and serological features in Egyptian SLE patients and their first degree relatives [FDRs] in comparison to unrelated healthy controls [UHCs] were examined, in order to identify individuals at the greatest risk for clinical illness. Methods In a cross-sectional study, blood samples were drawn from 54 SLE patients, 93 of their FDRs who consented to enroll into the study and 76 UHCs. Measurement of serum IFN-alpha by a modified ELISA was carried out. Data were analyzed for associations of serum IFN-alpha levels with autoantibodies titer. Results Mean serum IFN-alpha in FDRs was statistically higher than the UHCs and lower than in SLE patients [P < 0.0001] and it was correlated with ANA titer [r = 0.6, P < 0.0001] and anti ds DNA titer [r = 0.62, P < 0.0001]. Conclusion IFN-alpha is a crucial player in the complicated autoimmune changes that occur in SLE and serum IFN-alpha can be a useful marker identifying persons who are at risk of future disease development
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Index: IMEMR (Eastern Mediterranean) Main subject: Autoantibodies / Family / Interferon-alpha Limits: Female / Humans / Male Language: English Journal: Egypt. J. Med. Hum. Genet. Year: 2011

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Index: IMEMR (Eastern Mediterranean) Main subject: Autoantibodies / Family / Interferon-alpha Limits: Female / Humans / Male Language: English Journal: Egypt. J. Med. Hum. Genet. Year: 2011