3-[[2-chloroquinolin-3-yl]methyl]quinazolin-4[3H]-ones as potential larvicidal agents

ABSTRACT

The larvicidal effect of series of 3-[[2-chloroquinolin-3-yl]methyl]quinazolin-4[3H]-ones, 5a-e, against Chironomus tentans Fabricius has been investigated. The results showed that tested compounds demonstrated strong larvicidal activity, and caused high percentage of mortality after 24 h at the doses of 40-100 microg/ml, especially in the case of 3-[[2-chloro-8-methyquinolin-3-yl]methyl]quinazolin-4[3H]-one, 5b, that act as a promising larvicidal agent