To evaluate clinical efficacy of intravenous midazolam alone and along with propofol for sedation in patient management during interventional endoscopic procedures

ABSTRACT

Ample patient's sedation is a requisite for most interventional endoscopic procedures. A study was conducted to evaluate clinical efficacy of sedation using short acting anesthetic propofol with midazolam than midazolam alone in patient management during diagnostic and therapeutic endoscopic procedures. Prospective observational study. This study was conducted at radiology suite and endoscopy unit, by Department of Medicine, Gastroenterology and Hepatology Division, Holy Family Hospital, Rawalpindi, from 23-12-2009 to 21-6-2010. A total of ninety two patients undergoing endoscopic procedures randomly received either midazolam [n = 47, group A] or propofol plus midazolam [n= 45, group B] sedation. Patient vital sign's were noted as well as recovery scores, patient's tolerance of the procedure [visual analog scale]. Modified Richmond Agitation-Sedation Score [RASS Scale] was used to assess degree of sedation. The immediate and intermediate recovery was assessed using Steward's recovery score and Post Anesthesia Discharge score [PADS] respectively. Chi- square test value was 79.23 with P value of 0.001 and is significant, while Correlation co-efficient[r] value was 0.800 and the correlation was significant at 0.02 level. Propofol along with midazolam is safe for interventional endoscopic procedures under adequate patient monitoring and is more effective than sedation with midazolam alone as post procedural recovery is concerned while sedation efficacy being similar