25-Hydroxyvitamin D is closely related with the function of the pancreatic islet beta cells

ABSTRACT

This study is to investigate the relationship between 25-Hydroxyvitamin D [25-OH-D] and pancreatic islet beta cell function under different glucose tolerance statuses in China. Totally, 180 patients with type 2 diabetes mellitus [DM group], 178 patients with impaired fasting glucose/impaired glucose tolerance [IFG/IGT group], and 160 normal control subjects [NGT group] were included to measure their body parameters and biochemical parameters. In oral glucose tolerance test, fasting serum 25-OH-D was assessed by the enzyme-linked immunosorbent assay [ELISA]. Homeostasis model assessment for insulin resistance [Homa-IR], insulin acuity index [IAI], beta -cell function index [Homa-BCF] as well as secretion index [IS] were determined. The levels of 25-OH-D, IAI and Homa-BCF in the DM group and IFG/IGT group were significantly lower than that in NGT group [P < 0.05]. Homa-IR in DM group and IFG/IGT group was significantly higher than that in the NGT group [P < 0.05]. Pearson correlation analysis and partial correlation analysis showed that 25-OH-D was positively correlated with fasting insulin [FINS] and Homa-BCF [P < 0.05]. Multiple stepwise regression analysis showed that 25-OH-D was one of the influential factors of pancreatic islet beta cell function in patients with type 2 diabetes mellitus. Our results suggest that 25-OH-D is closely related with the function of the pancreatic islet beta cells and is one of the influential factors of pancreatic islet beta cell function