Your browser doesn't support javascript.
loading
Toxicity and antitumour activity of three novel antibiotics in relation to their effects on protein, DNA and RNA syntheses
Egyptian Journal of Microbiology. 1989; 24 (2): 235-246
in English | IMEMR | ID: emr-12743
ABSTRACT
The antimicrobial activity, toxicity and antitumor activity of three new antibiotics were investigated in conjunction with their effects on protein and nucleic acids synthesis of some bacterial strains. The new antibiotic vinaceomycin, did not show any toxic effect to normal Swiss albino mice at a concentration up to 500 mg/kg body weight, meanwhile it exhibited an in vivo antitumor effect against Ehrlich ascites tumor [33% increase in MST]. Both xanthominomycin and rubrominomycin which act as inhibitors of DNA synthesis, showed a very slight toxicity [10%] to normal Swiss albino mice at a concentration o f450mg/kg body weight but they did not show a significant antitumor effect against Ehrlich ascites tumor
Subject(s)
Search on Google
Index: IMEMR (Eastern Mediterranean) Main subject: Mice Language: English Journal: Egypt. J. Microbiol. Year: 1989

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Index: IMEMR (Eastern Mediterranean) Main subject: Mice Language: English Journal: Egypt. J. Microbiol. Year: 1989