Novel substituted-aminocoumarins as potential antimicrobial agents

ABSTRACT

The synthesis of a novel series of substituted-aminocoumarins [II], [III] and [IV] and the preliminary evaluation of their in vitro antimicrobial activity are described. The reaction of 4- hydroxycoumarin [I] with a number of primary or cyclic secondary amines afforded the corresponding 4-aminocoumarins derivatives [II]. Likewise, reacting the same substrate with different sulpha-drugs furnished the respective 4-[4-[N-substituted-sulphamoylphenyl]] -aminocoumarins [III]. On the other hand, Mannich reaction of [I] with formaldehyde and certain amines yielded the desired 4-hydroxy 3- substituted-aminomethyl-coumarins [IV]. The antimicrobial screening has revealed that some of these novel compounds possess moderate activity against Bacillus subtilis and Bacillus pumitis