Indirect atomic absorption spectrometric determination of 17, a-ethinylestradiol, lynestrenol, norethynodrel, ethchlorvynol and methyplenynol carbamate

ABSTRACT

Two sensitive indirect atomic absorption spectrometric [AAS] procedures are described for the determination of five monoacetylenic compounds. The first procedure is based on the formation of the copper acetylides, dissolving the acetylides in dilute nitric acid solution, followed by AAS measurement of the copper content. 17, alpha-ethinylestradiol, lynoestrenol, norethynodrel, ethchlorvynol [placidly] and methylpentynol carbamate are determined with mean percentage accuracies; 99.5 +/- 0.425, 100.27 +/- 0.678, 100.09 +/- 1.27, 100.56 +/- 1.749 and 100.64 +/- 2.04, respectively. The second procedure depends on the precipitation of certain monoacetylenic compounds as silver acetylides, followed by extraction with an organic solvent and measurement by AAS, 17, alpha- ethinylestradiol, lynoestrenol, norethynodrel and methylpentynol carbamate are determined by this technique with mean percentage accuracies; 99.5 +/- 0.58, 100.0 +/- 0.9115, 99.8 +/- 0.558 and 99.4 +/- 0.538, respectively