Influence of exposure to vapour of certain pyrethroids household mosquito repellant preparations on the neurobehavioral action of fluoxetin in rats
Journal of Drug Research of Egypt. 2007; 28 (1-2): 107-115
in English
| IMEMR
| ID: emr-128739
ABSTRACT
The environment includes increasing number of synthetic chemical compounds that cause environmental contamination . One of the most popular contaminating compounds are pyrethroids insecticides .Therefore, their wide spread use in agriculture and puplic health stimulated our attention for studying their possible toxic effect[s] on drug action .Fluoxetine is a selective inhibitor of serotonin reuptake which is widely used as an antidepressant . The aim of this work was to study the effect of inhalational exposure to vapour of two commonly used mosquito repellant preparations containing pyrethroids on the neurobehavioural action of fluoxetine . Sprague Dawley adult male rats were allocated into 3 main groups namely, control, and Ezalo and Ragon exposed groups .Exposure was performed 20 mm/day for 7 days in a static chamber . Twenty four hours later, i.p injection of fluoxetine [10 mg/kg] was performed . Contents of serotonin, norepinephrine and dopamine were determined in differtent brain regions one hour after fluoxetine injection . Behavioural parameters were also determined using open field and swimming test techniques.The obtained results showed that pre-exposure to Ezalo vapour induced significant increase in ambulation and rearing frequencies, while pre-exposure to Ragon vapour induced significant increase in ambulation, grooming and rearing frequencies as compared to fluoxetine-treated animals . Contents of serotonin and dopamine were also significantly altered in most brain regions .The obtained changes in the neurobehavioural parameters may be due to the effect[s] of pyrethroids and or the accompanying substances present in the mosquito repellant preparations on the biotransformation of fluoxetine
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Behavior, Animal
/
Fluoxetine
/
Selective Serotonin Reuptake Inhibitors
/
Neurobehavioral Manifestations
/
Insect Repellents
/
Insecticides
Limits:
Animals
Language:
English
Journal:
J. Drug Res. Egypt
Year:
2007
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