Bromopyrrole alkaloids from marine sponge Agelas oroides
Mansoura Journal of Pharmaceutical Sciences. 2007; 23 (1): 39-52
in English
| IMEMR
| ID: emr-128800
ABSTRACT
Following a bioassay-guided approach four bromopyrrole alkaloids, oroidin [1], 4,5-dibromopyrrole-2-carboxanijde [2], 4,5-dibromopyrrole-2-carboxylic acid [3] and 4,5-dibromopyrrole-2-[N methoxymethyl] carboxamide [4], were isolated from the bioactive ethyl acetate extract of the tropical marine sponge Agelas oroides. The structures of the isolated compounds were elucidated using their UV, NMR [I D and II D] and mass spectra. Fish feeding, brine shrimp, cytotoxic activity against L5178Y and Hela cell lines, protein kinase inhibition test and the antimicrobial activities for the isolated compounds were investigated. The fish-feeding assay showed that the total alcoholic extract was highly active and the major compound, oroidin, is responsible for this activity [in concentration of 80 mg/10 ml]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Arginine
/
Artemia
/
Pyrroles
/
Agelas
/
Alkaloids
Language:
English
Journal:
Mansoura J. Pharm. Sci.
Year:
2007
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