Evaluation the effect of dill [Anethum graveolens L .] and coriander [sativum L.] on lipid profile, liver and kidney functions in hypercholesterolaemic rats

ABSTRACT

Cardiovascular disease is the most important adult health problem in the world. Epidemiological studies and laboratory experiments have shown that fruit and vegetable consumption has protective effects against cardiovascular disease. So that, the aim of this study is to investigate, the hypocholesterolaemic effects of Dill [Anethum graveolens L.] and Coriander [Coriandrum sativum L.] in two levels 5 and 10% for 6 weeks in hypercholesterolemic rats and their effects on liver and kidney functions. Thirty six rats were divided into six groups, [each of 6 rats] as follow, first group [control negative] fed on basal diet only, second group [control positive] fed on hypercholesterolemic diet [basal diet, 1% cholesterol, 0.25% bile salt and 15% beef tallow], third groups fed on hypercholesterolemic diet supplemented with 5% coriander, fourth groups fed on hypercholesterolemic diet supplemented with 10% coriander, fifth group fed on hypercholesterolemic diet supplemented with 5% dill, and the sixth group fed on hypercholesterolemic diet supplemented with 10% dill. At the end of the experimental period [6 weeks] blood was collected then lipid profile and liver and kidney functions were determined in the serum. The results indicated that, consumption of dill or coriander with 5% or 10% significantly [P<0.05] decreased the mean value of serum total cholesterol, triglycerides, LDL-C and VLDL-C and significantly increased serum HDL-C as compared to control positive group. Also both dill and coriander significantly [P<0.05] improved liver and kidney functions. It was observed that no significant differences between the two tested levels and also between dill or coriander, It is concluded that dill and coriander have a significant lipid lowering effects and are promising hypocholesterolemic agents. Further scientific efforts are certainly required to establish the exact mechanism of action using the purified active components of them