Effect of Hyoscine-N-Butyl bromide [buscopan] in accelerating first stage of labor

ABSTRACT

To determine the effect of Hyoscine-N-Butyl Bromide [Busocpan] in accelerating first stage of labor and its relationship to the presence or absence of fetal membrane. The study was carried out between 1st May, 2007 and 3rd October, 2007 at Jidhafs Maternity Hospital in the Kingdomof Bahrain. A quasi-experimental prospective randomized control study was conducted on 92 primigravidas with single cephalic pregnancies who underwent spontaneous labor and who were not subjected for augmentation with any drug in active phase of labor. Sixty four patients were subjected to 40 mg intra-muscular injection of Busocpan and 28 acted as control. The rate of cervical dilatation was compared in both groups. The duration of fist stage of labor was 3.6 +/- 3.0 hours [mean +/- Standard deviation] for the Busocpan group and 4.7 +/- 2.9 hours [mean +/- SD.] for the control group. On comparing the mean of the duration of first stage of labor amongst different subgroups, it was found that the difference was only statistically significant in Buscopan group with absent membranes as compared to Busocpan group with intact membranes. Hyoscine-N-Butylbromide [Buscopan] was not effective in shortening the first stage of labor for primigravidas in comparison to control. However, Busocpan proved to be highly effective in shortening first stage of labor among patients with absent fetal membranes as compared to those who received Busocpan when their fetal membranes were present