Premature and early menopause: risk factors is Jordanian women

ABSTRACT

To identify risk factors associated with the onset of premature [<40 years] and early [40-45 years] menopause in a sample of Jordanian women. This prospective study was undertaken at Princess Aisha Medical Complex, Amman between August 2007 and February 2008. A total of 1,000 postmenopausal women were included. Factors taken into consideration were age at menarche, age at first delivery, parity, number of miscarriages, history of gynaecological or obstetric surgeries [ovarian, tubal and /or uterine], smoking status and history of premature menopause in first-degree relatives. Out of the 1,000 women, 129 [12.9%] had had menopause before the age of 46 years 27 [2.7%] before the age of 40 and 102 [10.2%] before the age of 46 years. In these groups, the only statistically significant factor was history of premature menopause in fist-degree relatives. Interestingly, in women who had had menopause after the age of >/= 46 years, the rate of hysterectomies was statistically higher. Early and premature menopause is strongly associated with history of premature menopause first-degree relatives. No other factors studied proved to have any statistical significance: