Successful treatment of steroid-refractory autoimmune thrombocytopenia associated with Castleman disease with anti-CD-20 antibody [rituximab]
Hematology, Oncology and Stem Cell Therapy. 2011; 4 (2): 100-102
in English
| IMEMR
| ID: emr-129766
ABSTRACT
Multicentric Castleman disease [MCD] is a lymphoproliferative disorder of incompletely understood etiology and with various clinical presentations. The best therapeutic option for this disease is not well established. MCD is known to be associated with autoimmune phenomena. A 70-year-old female patient of MCD with progressive nodal disease associated with autoimmune thrombocytopenia failed steroid treatment and showed a transient response to intravenous immunoglobulin. The patient achieved complete recovery of her platelet count and a very good response in nodal disease after 3 weekly doses of anti-CD-20 antibody [rituximab]. Anti-CD20 antibody treatment could be a good therapeutic option for MCD, mainly when associated with immune-related disorders
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Castleman Disease
/
Treatment Outcome
/
Antibodies, Monoclonal, Murine-Derived
Type of study:
Case report
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Hematol. Oncol. Stem Cell Ther.
Year:
2011
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