Human Leukocyte Antigen-G Expression on Dendritic Cells Induced by Transforming Growth Factor-beta1 and CD4[+] T Cells Proliferation
IBJ-Iranian Biomedical Journal. 2011; 15 (1,2): 1-5
in English
| IMEMR
| ID: emr-129770
ABSTRACT
During antigen capture and processing, mature dendritic cells [DC] express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta 1 [TGF-beta1] cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is to evaluate the effect of TGF-beta1 on the induction of human leukocyte antigen-G [HLA-G] expression on the DC which is derived from monocyte. Methods:
In this study, we evaluated the effect of TGF-beta1 in induction HLA-G expression on the monocyte-derived DC by flowcytometry and then CD4[+] T cell proliferative responses in the presence of DC-treated TGF-[beta1] was studied.Results:
The results of this study showed that DC bearing HLA-G down-regulated activation of CD4[+] T cells and production of IL-6 and IL-17 in comparison with control [P<0.05].Conclusion:
It is concluded that TGF-beta1 has an important regulatory role in CD4[+] T cell proliferation by increasing HLA-G on DC and these cells can probably prevent unexpected immune responses in vivo
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Dendritic Cells
/
CD4-Positive T-Lymphocytes
/
Cell Differentiation
/
Interleukin-6
/
Interleukin-17
/
Cell Proliferation
/
B7-2 Antigen
Limits:
Humans
Language:
English
Journal:
Iran. Biomed. J.
Year:
2011
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