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Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine
Pakistan Journal of Pharmaceutical Sciences. 2011; 24 (3): 251-254
in English | IMEMR | ID: emr-129849
ABSTRACT
Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine [5-HT] acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine [m-CPP] at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine [a component of coffee and tea] or theophylline [a component of tea] as a sole source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may, attenuate anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed
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Index: IMEMR (Eastern Mediterranean) Main subject: Piperazines / Theophylline / Caffeine / Serotonin Receptor Agonists / Rats, Wistar / Drug Interactions / Motor Activity Limits: Animals Language: English Journal: Pak. J. Pharm. Sci. Year: 2011

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Index: IMEMR (Eastern Mediterranean) Main subject: Piperazines / Theophylline / Caffeine / Serotonin Receptor Agonists / Rats, Wistar / Drug Interactions / Motor Activity Limits: Animals Language: English Journal: Pak. J. Pharm. Sci. Year: 2011