Antidiabetic and hypolipidemic effects of different fractions of coccinia cordifolia L. on normal and streptozotocin-induced diabetic rats
Pakistan Journal of Pharmaceutical Sciences. 2011; 24 (3): 331-338
in English
| IMEMR
| ID: emr-129859
ABSTRACT
The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia Linn. [150 mg/kg body weight] on normal and streptozotocin [STZ]-induced diabetic rats for one day experiment. Single doses [150 mg/kg, i.p.] of C. cordifolia extracts were given to normal and diabetic rats. The fasting blood glucose [FBG], serum triglyceride [TG] and serum total cholesterol [TC] levels were investigated in normal and STZ-diabetic rats on 0, 1, 2, 3, 6, 10, 16, and 24[th] hours. In normoglycemic rats the pet-ether and ethyl acetate fractions of C. cordifolia reduced blood glucose level significantly [39.66% and 40.68% at 16[th] and 24[th] hour respectively]. In the STZ-diabetic rats pet-ether and ethyl acetate fractions also reduced blood glucose level significantly [50.39% and 50% at 10[th] and 24[th] hour respectively]. Ethyl acetate fraction is most effective which reduced total cholesterol level by 31.04% and 36.69% in normal and STZ-diabetic rats respectively. Ethyl acetate fraction reduced triglyceride level by 43.82% and 42.01% in normal and STZ-diabetic rats respectively. Our results indicate that pet-ether and ethyl acetate fractions of C. cordifolia have potentiality against diabetes
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Triglycerides
/
Blood Glucose
/
Plant Extracts
/
Cholesterol
/
Plant Leaves
/
Rats, Long-Evans
/
Diabetes Mellitus, Experimental
/
Hypoglycemic Agents
/
Phytotherapy
Limits:
Animals
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2011
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