importance of serum prostate specific antigen levels in demonstration of potency between the extent and the degree of aggressiveness of inflammation in patients with asymptomatic chronic prostatitis

ABSTRACT

To compare the extent and the degree of aggressiveness of inflammation on the total prostate specific antigen [t-PSA], free PSA [f-PSA], free / t-PSA ratio, and PSAD values in patients with chronic prostatitis. Retrospective, descriptive study. Yuksek Ihtisas Training and Research Hospital, Turkey. Fifty-five patients with serum t-PSA levels higher than 4 ng / ml and with chronic prostatitis were included. Transrectal ultrasound guided biopsy was taken from patients with serum PSA levels higher than 4 ng / ml. Histological sections of the prostatic tissues were scored using the extent and aggressiveness of inflammation seen, on a four point scale from 0 to 4. Serum PSA levels in different inflammation grades were compared. Kruskal-Walls variance analysis was used for inter-group assessment. In both groups scoring; no patient was in grade O. On the extent of inflammation group scoring; 2, 36, and 17 patients had grade 1, 2, 3, respectively. In this group, unlike the t-PSA values, the extent of inflammation was significant in PSA-D [p = 0.004] with a negative correlation in f / t PSA values. On the aggressiveness of inflammation group scoring; 18, 23, and 14 patients had grade 1, 2, 3, respectively. In this group, no statistical difference was found in terms of t-PSA, but statistical differences were monitored in terms of f-PSA, f / t PSA, and PSA-D values [p = 0.03, 0.002, 0.01, respectively]. High serum PSA levels in patients with asymptomatic chronic prostatitis may correlate with the degree of extent and aggressiveness of inflammation