Hemorrhagic shock in deoxycortisone [Doc] -saline hypertensive rats: the effect of naloxone

ABSTRACT

The hemodynamic changes and metabolic alterations during hemorrhagic shock were determined in deoxycorticosterone-saline hypertensive [DOC-saline] rats and compared with those of normotensive control rats. The shocked DOC-saline rats showed more drop in the arterial pressure, an early rise and subsequent decline in plasma glucose and lower plasma triglyceride than the normotensive control rats. Survival rats were equal. Treatments with naloxone 1 mg/kg/hr produced a more dramatic rise in the arterial pressure of the normotensive than the DOC- saline rats; survival rates of both groups were greatly improved. naloxone reduced the decline in plasma glucose during the late hours of hemorrhagic shock and increased plasma triglycerides in DOC-saline rats. It is concluded that naloxone is less effective in shocked DOC-saline hypertensive rats than in shocked normal control rats