Anticonvulsant activity of Alangium salvifolium stem bark

ABSTRACT

The anticonvulsant activity of methanolic extract of Alangium salvifolium stem barks in doses 100, 200, 400, 500 mg/kg in mice was assessed using maximum electroshock seizure [MES] test and pentylenetetrazol [PTZ]-induced convulsion in albino mice. The lithium pilocarpine model of status epilepticus was also used to assess the anti-convulsant activity in rats. The methanolic extract of Alangium salvifolium stem bark did not reduce the duration of tonic hindleg extention in the MES test even in the dose of 500 mg/kg. However, this extract significantly and dose dependently delayed the onset of clonis convulsions induced by pentyletetrazol. The dose of 100 mg/kg afforded protection to all animals. The methanolic extract of Alangium salvifolium stem bark inhibited the PTZ and lithium pilocarpine-induced convulsions but MES induced convulsions condition remained unchanged