Etiology of primary amenorrhoea: a study of 50 cases

ABSTRACT

Amenorrhoea is one of the commonest reasons for referral of female patients to a gynaecology clinic. It is subdivided into primary and secondary. The etiology of primary amenorrhoea is complex. The aim of this study was to determine the etiological factors of primary amenorrhoea and to find out the mean age at first presentation. Descriptive Study. This Study was conducted in the department of Obstetrics and Gynaecology Foundation University Medical College Fauji Foundation Hospital Rawalpindi, from 1[st] January 2005 to 31[st] December 2007. 50 girls who reported to gynae outpatient department with the complaint of primary amenorrhoea were included in the study after informed consent. Detailed history, clinical examination and investigations [transabdominal ultrasonography, hormonal profile including serum FSH, LH and prolactin, karyotyping] were recorded in proformas for analysis. A total of 50 girls reported to gynae OPD with complaints of primary amenorrhoea over a period of 24 months with the mean age of 18.5 years at initial presentation. Almost half of the girls [48%] with normal secondary sexual characteristics had anatomical defects, rokitansky;s syndrome being the commonest, while those with absent secondary sexual characteristics had constitutional delay as the commonest cause. Mean age at first presentation is late. Anatomical causes are the commonest. Turner's syndrome is relatively uncommon in our patients