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Histopathological hepatoprotective effects by echinops echinatus A plant from Cholistan desert
Medical Forum Monthly. 2011; 22 (4): 41-43
in English | IMEMR | ID: emr-131180
ABSTRACT
Aerial parts of Echinops Echinotus [EE] were subjected to in vivo histological hepatoprotective study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan desert, Pakistan. Experimental study. The study was conducted at PCR lab Multan. The animals were randomly divided into three groups, containing 10 rabbits in each group. Histological hepatoprotective effects of pre-treatment with aerial parts [ethanolic extract] of EE [500 and 750 mg/kg/day PO for 7 days] against CCI[4] [0.75 ml/kg, S/C] intoxicated rabbits were evaluated by liver histological observations. Silymarin [100 mg/kg/day PO for 7 days] was used as a standard hepatoprotective drug. CCI[4] intoxicated group had significant histological changes [marked fatty changes etc.] as compared to normal control group. However, EE extract produced significant histological hepatoprotective changes. Therefore, the outcome of present study supports the traditional behaviour on hepatoprotective effects of Echinops Echinaus [aerial parts]
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Index: IMEMR (Eastern Mediterranean) Main subject: Rabbits / Liver / Phytotherapy Limits: Animals Language: English Journal: Med. Forum Mon. Year: 2011

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Index: IMEMR (Eastern Mediterranean) Main subject: Rabbits / Liver / Phytotherapy Limits: Animals Language: English Journal: Med. Forum Mon. Year: 2011