[Protein S, C and antithrombin deficiency: Association to myocardial infarction and thromboembolism in young]
Tunisie Medicale [La]. 2012; 90 (4): 316-319
in French
| IMEMR
| ID: emr-131478
ABSTRACT
The pathogenesis of myocardial infarction [MI] in young involves new factors including constitutional or acquired thrombophilia. To determine in patients = 50 years, the association between coagulation factors deficiency, myocardial infarction and cardiovascular events during follow-up. Protein C [PC], PS and antithrombin [AT] were screened in 50 patients admitted for acute MI and in a healthy control group. Univariate and multivariate analysis were performed using SPSS 11.5 version. PS and PC deficiency were associated to MI [respectively 24% vs 0%, p=0.001 and 14% vs 0%, p=0.016], independently for PC. No AT deficiency was detected in both groups. During followup, PS and C deficiency were predictive for venous thrombosis [p<0.05] and PS deficiency for pulmonary embolism. Protein C and S deficiency may play an important role in MI in young and also in thromboembolic complications during follow-up. Nevertheless, therapeutic implications remain controversial
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pulmonary Embolism
/
Thromboembolism
/
Protein C
/
Protein S
/
Protein S Deficiency
/
Thrombophilia
/
Venous Thrombosis
/
Antithrombin III Deficiency
/
Protein C Deficiency
Limits:
Female
/
Humans
/
Male
Language:
French
Journal:
Tunisie Med.
Year:
2012
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