role of the histaminergic system on the inhibitory effect of ghrelin on feed intake in broiler chickens

ABSTRACT

This study was conducted to investigate the possible involvement of the histaminergic system in the mediation of ghrelin-induced feeding behavior in broilder chickens. In the trial 1, the effect of intracerebroventricular [ICV] injection of ghrelin on feed intake was examined in 3-h feed-deprived broiler chickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine [an H[1] receptor antagonist] was measured at 2-h post injections. Infusion of ghrelin [0.3, 0.6 and 1.2 nmol] decreased feed intake dose-dependently [P<0.05]. Pre-treatment of chlorpheniramine [100 micro g] attenuated the inhibitory effect of ghrelin results suggest that there is an interaction between ghrelin and the histaminergic system [through H[1] receptors] on control of feed intake in broiler chickens