[Comparison of intraoperative hemodynamic parameters and post operative analgesia of gabapentin and tizanidine in patients with tibial fractures]

ABSTRACT

Preoperative consumption of some drugs can control intra operative and post operative pain. Gabapentin and Tizanidine analgesic effects have been studied but a comparison between analgesic effects of these two drugs has not been studied before. We studied 60 patients with tibial fractures between 15 to 80 years. They were divided into two groups 30 patients were given 300 mg Gabapentin orally 1 hour before operation [Group G], and 30 patients were given 8 mg Tizanidine by oral route 1 hour before operation [Group T]. Pain was assessed 1 hour before until 12 hours post operation using Visual Analogue Scale [VAS]. All patients had general anesthesia. Vital signs and fentanyl consumption during Surgery, the first time morphine was needed and the total dose of Morphine after operation were assessed. Systolic, diastolic blood pressure and heart rates during operation between two groups were not statistically significant. intra operative fentanyl dose in group G was significantly less than group T[P = 0.001]. The first time morphine was needed in group G was significantly longer than group T [P = 0.001] and total dose of Morphine Consumption during 12 hours after operation in group G was significantly less than group t [P = 0.003]. VAS was only different between two groups 12[th] hours. After operation. Preoperative oral consumption of Gabapentin compared to Tizanidine might facilitate better analgesia and more opioid saving during and after operation