Use of tigecycline [tygacil] against drug resistant organisms in eastern region

ABSTRACT

This study was designed to look for sensitivity and resistant pattern of tigecycline in different gram positive and gram negative infections which were resistant to different antibiotics and also look for various methods to prevent drug resistance against tigecycline [tygacil] group of antibiotic. Three hundred seventy five [375] isolates which includes MRSA [Methicillin Resistant Staphylococcus Aureus], VRE [Vancomycin Resistant Enterocooci], ESBL [Extended Spectrum Beta Lactamase], Stenotrophomonas maltophilia and MDR [Multi Drugs Resistant] Acinetobacter species were identified with the help of colonial characteristics, gram staining, biochemical reactions including API strips system, and special techniques used for each organism. Sensitivity was done with help of disc diffusion [Kirby Bauer] method for tigecycline [tygacil] 15 ug disc provided by company. This is a retrospective study which has showed that MRSA were 100% sensitive to tigecycline and VRE were also 100% sensitive to this antibiotic. The ESBL were 90% sensitive and Stenotrophomonas maltophilia 87% to tigecycline. The MDR Acinetbacter species were only 41% resistant which was high in 2008 as compared to overall sensitivity pattern. Male and female were almost equal in this study. Highest number of cases was reported from 70-80 years age group. The different isolates were from different locations from human body and different wards including ICU [Intensive Care Unit]. Tigecycline exhibit high in vitro activity against most of the commonly encountered gram positive and gram negative resistant organisms which were pathgens in this region. We should take care not to get antibiotic resistance to be developed against tigecycline by appropriate uses and preventive measures [hand hygiene etc.]