[Effects of different growth factors on new bone formation: a systematic review]
Journal of Islamic Dental Association of Iran [The]-JIDA. 2012; 24 (2): 150-167
in Persian
| IMEMR
| ID: emr-132446
ABSTRACT
Using different osteogenic growth factors, which is still under investigation, is a favorable method for bone regeneration. This systematic review is aimed at evaluating the effects of different growth factors and their carriers on osteogenesis. Electronic databases [Medline, EMBase and Cochrane] were searched by the authors for articles published from 1999 to April 2010. Clinical and animal studies evaluating bone formation by applying a specific growth factor and the related carrier were included in this investigation. Obtained data were organized in a table and evaluated through a qualitative analysis. Sixty-three studies most of which evaluated the effects of BMP-2 osteogenesis in different models were included in this study. Totally, twenty-five carriers were applied with different growth factors in the experiments. Among these carriers, poly lactic- co glycolic acid [PLGA], hydroxy apatite/tricalcium phosphate/absorbable collagen sponge [HA/TCP/ACS] and BioOss were the most frequently used carriers with the growth factors in bone regeneration studies. The current evidence, although not strong enough, confirms that BMP-2 has more favorable results in osteogenesis compared with other factors. The carrier scaffold, methods of measurement [histologic or radiographic], type of animal, defect diameter and the length of follow-up are the variables that should be matched before reaching definite results for the effect of growth factors in bone regeneration
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Osteogenesis
/
Polyglycolic Acid
/
Calcium Phosphates
/
Lactic Acid
/
Intercellular Signaling Peptides and Proteins
/
Bone Morphogenetic Protein 2
Type of study:
Systematic reviews
Language:
Persian
Journal:
J. Islam. Dent. Assoc. Iran
Year:
2012
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