[Effect of Phoenix Dactylifera Spathe hydroalcoholic extract on chronic pain in mice]

ABSTRACT

In Persian traditional medicine, many medicinal plants have been used as analgesics; in which one of them is the distillate of Phoenix Dactylifera Spathe [PDS] known as "Tarooneh". This study was conducted to assess the antinociceptive effect of Tarooneh [PDS] hydro alcoholic extract on inflammatory pain induced by formaline in mice. In this study, 28 male albino mice weighting 25 - 30 grams, were randomly and equally divided into 4 groups. 2, 20 and 200 mg/kg PDS extract and vehicle were administered intraperitomeally to the test and control groups respectively in a volume of 10 ml/kg. Animals were subjected to Formalin test as an animal model for inflammatory pain assessment. Mean pain score induced by formalin test in control group was 1.665 +/- 0.0599 while in test groups receiving 2, 20 and 200 mg/kg PDS extract were 1.079 +/- 0.0666, 0.9192 +/- 0.0822 and 0.3842 +/- 0.0658 respectively. data from this study revealed that PDS extract, significantly and dose dependently, attenuated the inflammatory formalin induced pain in mice