[Effects of regular aerobic exercise on cardiorespiratory fitness and levels of fibrinogen, fibrin D-dimer and uric acid in healthy and inactive middle aged men]

ABSTRACT

The aim of this study was to investigate the effects of three months regular aerobic exercises on the levels of fibrinogen, fibrin D-dimer, uric acid, white blood cells count [WBC], red blood cell distribution width [RDW], body mass index [BMI] and cardiorespiratory fitness in middle aged healthy and inactive men. To implementation of this semi-experimental research, from employees in Ferdowsi university, 21 middle aged men with available method were selected and assigned into experimental [N=11, age 44.7 +/- 4.3 y, height 1.73 +/- 0.04 m, weight 81.8 +/- 9.36 kg] and control [N=10, age 41.2 +/- 8 y, height 1.73 +/- 0.07 m, weight 78.2 +/- 14.8 kg] groups. The experimental group performed an aerobic exercise protocol with the intensity of 75% to 85% of their maximum heart rate for three months [three days a week]. Before and after trainings, aerobic power, body composition variables and fasting levels of blood variables were measured. Data analysis showed a significant elevation of RDW, aerobic power and WBC and significant reduction of BMI and uric acid in experimental group [P<0.05], but no significant change was observed in the levels of fibrinogen and fibrin D-dimer. Considering reduction of some inflammatory atherosclerosis risk factors, aerobic exercise may be recommended for improvement of cardiovascular health in middle aged men