[Evaluation of discontinuation of antibacterial prophylaxis in children with vesicoureteral reflux]

ABSTRACT

Vesicoureteral reflex is the most important factor in urinary tract infection. For prevention of urinary tract infection [UTI] in children with vesicoureteral reflux [VUR], prophylactic antibiotics are used, but maybe accompany with uncompliance of the parents and also it must use for long time. So, this study aimed at comporison of evaluation of discontinuation of antibacterial prophylaxis in children with VUR. This semi experimental study was done in 54 children with low grade VUR [1, 2] and higher than 5 years old. None of them have had any episode of UTI since last year. They were divided in two groups, continue and discontinue of prophylactic drugs and were followed for at least one year. Then the risk and episode of recurrent UTI were compared in 2 groups. The data were analyzed by SPSS and P<0.05 was determined as significant. Mean age of patients were 7.8 +/- 2.5 years. Forty two [77.8%] children were girls and others [22.2%] were boys. Five episode of UTI were diagnosed in first group and 7 episodes for second group [P>0.05]. Also the risk of recurrent UTI was 1.5 time in girls. According to this study, discontinuing of prophylactic drug in children with grade I and grade II of VUR and after 5 years old is safe and there isn't increased risk of recurrent UTI