Oltipraz treatment in experimental schistosomiasis mansoni: III effect of high dose oral therapy on hepatic shift of worms and tissue bould ova pattern in infected mice

ABSTRACT

Oltipraz was given in a single oral dose of 500 mg/kg body weight to mice experimentally infected with the Egyptian strain of S. mansoni. The drug caused marked hepatic shift of the worms in comparison to the infected untreated controls. Hepatic shift of worms was apparent till the 30th day from Oltipraz administration, while pronounced back shift to mesenteric veins by the surviving parasites occurred 60 days post- treatment. The drug also caused death of all bilharzial eggs located inside tissues of the small intestines of infected mice and complete eradication of fecal eggs after the 5th, 7th, 20th, 30th and 60th days from therapy. These findings need the histopathological investigations